Multiple Chronic Conditions (MCC) means that a person is living with two or more chronic conditions at the same time. Currently, 1 out of 3 adult Americans have MCCs and for persons 65 and older 4 out of 5 Medicare Beneficiaries and a growing number of children have MCCs. This is the largest patient population and users of healthcare resources accounting for 64% of all clinician visits, 70% of all inpatient stays, 83% of all prescriptions, 71% of all healthcare spending, and 93% of Medicare spending.
Palliative care is symptom management in persons with multiple chronic conditions. The focus is on quality of life and not death. Palliative care should be integrated into the routine management of symptomatic chronic conditions such as heart failure, chronic obstructive pulmonary disease, cancer, chronic kidney disease and others. The effective management of symptoms prevents disease exacerbation, reduces hospitalization, maintains physical functioning, and improves quality of life.
Managing symptomatic multiple chronic conditions, prevents escalation and worsening of the underlying conditions. Proactive interventions to reduce the burden of symptoms such as pain, depression, insomnia, shortness of breath and others improves quality of life and promotes the ability to engage in meaningful and important activities.
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Putting health policy into perspective
Person-Centered Care in Multiple Chronic Conditions
Person-centered care as defined by the Agency for Healthcare Research and Quality (AHRQ) means that individuals’ values and preferences are elicited and once expressed, guide all aspects of their health care, supporting their realistic health and life goals. Person-centered care is achieved through a dynamic relationship among individuals, others who are important to them, and all relevant providers. This collaboration informs decision-making to the extent that the individual desires.
With support from the Agency for Healthcare Research and Quality, a learning collaborative comprised of frontline implementers, innovators, and researchers with expertise in person-centered care planning was formed to discuss models and implementation of PCCP. The learning collaborative participated in six learning sessions from June 2024 to January 2025. Below is a compendium of PCCP models, resources, and materials that were shared by community members during learning sessions.
PCCP models, resources, and materials:
Medication Safety

In 2023, the CDC reported that the most common types of adverse drug events are associated with allergic reactions, side effects, over-medication, medication errors, and drug–drug interactions. Healthcare advances in new drug development, older medications with newer indications for use, an aging population, and the expansion of prescription drug coverage may lead to an increase in these events. When nurses understand what determines evidence, how to implement guidelines as standard of care, and what establishes best practices to optimize medication safety, they can help prevent medication errors.

Patients have long associated trust and respect with nursing. However, recent incidents of nurses delivering inappropriate medications (wrong drug, wrong dose) have led to catastrophic consequences. Most notoriously, former nurse RaDonda Vaught was stripped of her nursing license and charged with reckless homicide and abuse of an impaired adult.

Anticholinergics, widely used in clinical practice for an extensive range of diseases, exert effects on circulation, respiration, alertness, and vision by blocking the action of acetylcholine (a neurotransmitter) within the cholinergic system.

Providers prescribe benzodiazepines (BZDs)—also known as anxiolytics, hypnotics, muscle relaxants, anticonvulsants, and amnestic medications—to manage several symptoms and conditions, including anxiety, insomnia, alcohol withdrawal, sedation, muscle spasms, agitation, and seizures.

To ensure safety and effective care, nurses must maintain their knowledge and understanding of opioid pharmacologic properties and best practices when caring for patients with acute and chronic non-cancer pain.