The APOL1 gene is recognized as a kidney risk gene. APOL1-mediated kidney disease is a rapidly progressive form of proteinuria kidney disease. Although this gene is autosomal recessive the risk comes from the genotype of both parents. Compared with other chronic kidney disease patients, those of African ancestry with a confirmed APOL1 gene variant progress to dialysis 9 to 12 years earlier. APOL1-mediated kidney disease is often associated not only with proteinuria but also with a rapid decline in eGFR, earlier onset of kidney disease (including adolescence), and leads to a mean age of kidney failure in the U.S. of 45 years. Patients are often asymptomatic. Richard Knight, co-founder of the APOL-1 Alliance (https://apol1alliance.org/), provides a patient perspective on this condition.

The post Richard Knight and the APOL1 Action Alliance (AAA) appeared first on Multiple Chronic Conditions.

Rosa Hart, a stroke certified registered nurse with the American Association of Neuroscience Nurses, describes new updates from the America Heart Association and the American Stroke Association’s January release of the 2026 Guideline for the Early Management of Patients with Acute Ischemic Stroke. This guideline replaces the 2018-2019 guideline and updates.

The post Update from the 2026 Guideline for the Early Management of Patients with Acute Ischemic Stroke appeared first on Multiple Chronic Conditions.

In this episode of the Wellbeing 4 Me podcast, host Renee McDonald sits down with Dr. Kim Kuebler, a Doctor of Nursing Practice with 43 years of clinical experience. Joining us all the way from Georgia, USA, Dr. Kuebler is the Editor in Chief of the Multiple Chronic Conditions Resource Center and a leading expert in managing complex patient care.

The post Dr. Kim Kuebler on The Silent Epidemic: Why Multiple Chronic Conditions Are Hitting Younger People appeared first on Multiple Chronic Conditions.

In this powerful discussion, we explore how palliative care is being redefined from a focus on the end of life to an emphasis on living better throughout illness. Our guest shares how health entrepreneurs and practitioners are pioneering new models of supportive care that give patients and their families dignity, resilience, and quality of life first.

The post Redefining Palliative Care: From End-of-Life to Lifelong Quality appeared first on Multiple Chronic Conditions.

Dr. Kim Kuebler, DNP, APRN, ANP-BC, FAAN and Laly Havern, PharmD, MS, BCACP discuss how to empower the patient by promoting a patient-centered care plan that ensures optimal outcomes.

The post Collaboration in Patient-Centered Care Planning: Navigating Oncology appeared first on Multiple Chronic Conditions.

Richard Knight, Bowie State University describes his patient journey and kidney transplant. He describes the need for patient education and self-advocacy.

The post Patient Perspective on Living with Chronic Kidney Disease and Multiple Chronic Conditions appeared first on Multiple Chronic Conditions.

In this webinar, Dr. Kim Kuebler, DNP, APRN, ANP-BC, FAAN goes over medication safety, which includes reviewing how long it takes a drug to come to market, describing the difference between an FDA approved medication and compounded medications, and much much more.

The post Medication Safety: Knowledge is Power appeared first on Multiple Chronic Conditions.

Eduardo Bruera MD, University of Texas MD Anderson Cancer Center describes the integration of palliative care into the primary care setting. Palliative care used in the management of multiple chronic conditions, improves physical functioning, quality of life and reduces acute exacerbations and hospitalization.

The post A Paradigm Shift: Integrating Palliative Symptom Management in Multiple Chronic Conditions appeared first on Multiple Chronic Conditions.

Paul Ciechanowski MD, University of Washington discusses how to integrate behavioral health in the primary care setting for persons living with multiple chronic conditions. He discusses clinical inertia and how this can influence health outcomes.

The post Integrating Behavioral Health in the Primary Care Setting appeared first on Multiple Chronic Conditions.

The post Kim Kuebler DNP, APRN, ANP-BC, FAAN appeared first on Multiple Chronic Conditions.